May 22, 2013 - Doctors should discuss the benefits and risks
of screening for lung cancer LDCT after today's publication in the New England
Journal of Medicine, to share the results of the first (of three planned)
Annual Exam NLST information of their patients. "Working for the
prevention of cancer, it is important to check if it can be diagnosed with
cancer really early. Analyzing the NLST participants at the beginning of annual
screening study shows that the number of cancer early detection in the CT arm is
significantly higher than the number of recognized hand chest X-ray, "says
Timothy Church, Ph.D., professor and biostatistician School of Public Health,
University of Minnesota, which participated in the NLST design was about
implementation and evaluation.
The church is also noted that the reduction in mortality
ultimate measure of a successful strategy for the prevention of cancer. NLST is
a large-scale, longitudinal, randomized clinical trial involving more than
53,400 participants in the study as either a standard or a hand LDCT chest
radiographs to assess whether lung cancer screening saves lives. Publication of
the results (NEJM, 2011) reported a 20 percent reduction in lung cancer
mortality among participants (all with high-risk disease) screened by chest
X-ray LDCT compared with those undergoing the inspection.
The authors report that the first examination results
reflect the NLST other large studies LDCT positive compared with the results of
X-ray chest, with the discovery of a positive test result [6369 compared to
2176 or] [7191 compared to 2387, or], further diagnostic procedures and other
more biopsies NLST saw invasive procedures [297 vs. 121, respectively], and
more lung cancer in the LDCT arm relative to the legs RT during the first round
of selection [292 vs. 190, respectively]. Although the results were widely
expected to announce a major cause of information on the exact differences
between the two branches of the document. "Although we see that CT gave
see more patients for additional testing, the question boils down to whether
the 20-percent reduction in the incidence of mortality is an additional
screening of high-risk patients should not be introduced," says Church.
Noted that although more follow- procedures compared with the radiograph LDCT
leg, make sure it is encouraging that the number of people, more invasive
monitoring of the process was actually very small.
Another encouraging result reported a high level of
compliance in the implementation of LDCT expertise in the study of 33 sites
conducted to study the screen image. "The areas that meet the low-dose CT
protocol specifications in 98.5 per cent of the studies conducted and an
amazing view of the many thousands of scans," says Denise R. Aberle, MD,
of the National investigator for NLST ACRIN main site and co-host researcher
for the team UCLA NLST. Aberle, a member of the Jonsson Comprehensive Cancer
Center, UCLA, Professor of Radiology and biotechnology and vice-president of
research in the field of radiology in Los Angeles, also stressed that the
results of the first screen clearly showing that CT screening program for lung
cancer with radiologists acquired a verbal and written, similar results to
those numbers, computer tomography of the same caliber or better than those
that are suitable for the NLST, like paper.
"What we learned from the analysis of the results of
the first screen provides doctors discuss with patients the same
characteristics, NLST participants (more than 55 current or former heavy
smokers) to share the facts," Church said. "These results also
caution against that blanket recommendations lung cancer screening because the
trade-off between the risk that all the unnecessary procedures and the fear of
dying from lung cancer is a unique individual."
"The publication of today still represents NLST type is
too important to screen for lung cancer in the proposal of the United
States," says Mitchell J. Schnall, MD, PhD, ACRIN Network Chair of the
group, co-chair of ECOG-ACRIN Cancer Research Group and chairman of the department
of radiology at the University of Pennsylvania . "Congratulations to the
team information NLST develop solutions NLST procedure patients, physicians and
health care policy manual. Continuing his efforts"
