The risk of lung
cancer associated with exposure to asbestos and asbestosis smoking
significantly increases when risk factors are combined, according to the
results of the study.
But smoking has become significantly reduce the risk of lung cancer after prolonged exposure to asbestos.
Steven B. Markowitz, MD, DrPH, professor of occupational and environmental medicine at Queens College in New York, and colleagues assess the study of the influence of personal contact with asbestos, asbestosis and smoking - and the relationship with the risk of developing lung cancer - in the exposed group asbestos.
The researchers examined the long-term North American insulators (N = 2377), and compared with male workers with no history of asbestos exposure (n = 54,243) who participated in the Cancer Prevention Study II.
Data from the group consisting of an insulator age, duration of operation and during early works as an insulator, smoking history, parenchymal asbestosis, asbestos pleural fibrosis and FEV1/FVC low (<65%).
Comparative data from the study to prevent cancer include smoking (past and present, never), pack-year categories (80-89 0-9 packs of cigarettes per year), years after his retirement for ex-smokers, and the number Deaths from lung cancer in 1982 - 2008.
The researchers calculated the mortality rate and the number of lung cancer deaths divided by the number of person-years for each group is chosen for each time period. Poisson regression modeling was used for all comparisons prevention insulator class group of cancer research. Cox modeling analyzes all data insulator group.
According to the survey was responsible for 339 (19%) deaths due to lung cancer insulator. In particular, the death rate from lung cancer associated with asbestos exposure in non-smokers (rate ratio = 3.6, 95% CI, 01.07 - 07.06), followed by asbestosis in non-smokers (rate ratio = 7.4, 95% CI, 4 - 13 : 07), and smoking without asbestos (rate ratio = 10.3, 95% CI 08.08 - 12.02).
"We found that each individual risk factor associated with an increased risk of developing lung cancer, while the combination of risk hazard continues to grow, and the combination of the three risk factors increases the risk of developing lung cancer by almost 37 times," Markowitz said in a press release.
Dual effect of smoking and asbestos were just added (rate ratio = 14.4, 95% CI 10.7 - 19.4), and in combination with asbestosis, the result was higher (odds ratio = 36.8 95% CI 30.1 to 46.)
The researchers found that the insulating mortality from lung cancer at age 10, quit after a half. Insulators, which had stopped smoking for more than 30 years have been very similar to the rate of lung cancer as insulators have never smoked.
"Asbestosis Asbestos without concomitant increases the risk of lung cancer in non-smokers and the risk of additional smoke," Markowitz and his colleagues wrote. "In addition, under the asbestosis risk of lung cancer with smoking and growing, it has a super-additive effect on the risk of developing lung cancer. This model is the difference in risk depending on the presence or absence of asbestosis continue smoking cessation. S risk of death from lung cancer among smokers agreed with insulators insulators never smokers left. "at least 30 years earlier
But smoking has become significantly reduce the risk of lung cancer after prolonged exposure to asbestos.
Steven B. Markowitz, MD, DrPH, professor of occupational and environmental medicine at Queens College in New York, and colleagues assess the study of the influence of personal contact with asbestos, asbestosis and smoking - and the relationship with the risk of developing lung cancer - in the exposed group asbestos.
The researchers examined the long-term North American insulators (N = 2377), and compared with male workers with no history of asbestos exposure (n = 54,243) who participated in the Cancer Prevention Study II.
Data from the group consisting of an insulator age, duration of operation and during early works as an insulator, smoking history, parenchymal asbestosis, asbestos pleural fibrosis and FEV1/FVC low (<65%).
Comparative data from the study to prevent cancer include smoking (past and present, never), pack-year categories (80-89 0-9 packs of cigarettes per year), years after his retirement for ex-smokers, and the number Deaths from lung cancer in 1982 - 2008.
The researchers calculated the mortality rate and the number of lung cancer deaths divided by the number of person-years for each group is chosen for each time period. Poisson regression modeling was used for all comparisons prevention insulator class group of cancer research. Cox modeling analyzes all data insulator group.
According to the survey was responsible for 339 (19%) deaths due to lung cancer insulator. In particular, the death rate from lung cancer associated with asbestos exposure in non-smokers (rate ratio = 3.6, 95% CI, 01.07 - 07.06), followed by asbestosis in non-smokers (rate ratio = 7.4, 95% CI, 4 - 13 : 07), and smoking without asbestos (rate ratio = 10.3, 95% CI 08.08 - 12.02).
"We found that each individual risk factor associated with an increased risk of developing lung cancer, while the combination of risk hazard continues to grow, and the combination of the three risk factors increases the risk of developing lung cancer by almost 37 times," Markowitz said in a press release.
Dual effect of smoking and asbestos were just added (rate ratio = 14.4, 95% CI 10.7 - 19.4), and in combination with asbestosis, the result was higher (odds ratio = 36.8 95% CI 30.1 to 46.)
The researchers found that the insulating mortality from lung cancer at age 10, quit after a half. Insulators, which had stopped smoking for more than 30 years have been very similar to the rate of lung cancer as insulators have never smoked.
"Asbestosis Asbestos without concomitant increases the risk of lung cancer in non-smokers and the risk of additional smoke," Markowitz and his colleagues wrote. "In addition, under the asbestosis risk of lung cancer with smoking and growing, it has a super-additive effect on the risk of developing lung cancer. This model is the difference in risk depending on the presence or absence of asbestosis continue smoking cessation. S risk of death from lung cancer among smokers agreed with insulators insulators never smokers left. "at least 30 years earlier
